B cells regulate luminal bile acid composition in the small intestine

Abstract Recent studies have demonstrated that bile acids (BA) influence immune cell homeostasis in the gut. However, whether and how, host response can BA biochemistry is unknown. This an important question to answer because small shifts composition gut significant pathophysiological consequences. Previously, we CD19 −/−mice, which a defect B activation consequently aberrant humoral response, develop intestine (SI) enteropathy associated with abnormal luminal composition. −/−mice are not B-cell-deficient present multiple phenotypes. Here, used cell-deficient JHminus;/minus; mice more effectively define this interaction. Results of our experiments provide three key observations. First, J H−/−mice altered SI pools compared their WT littermates. Second, adoptive transfer cells into neonatal led development normal rescued from enteropathy. Third, incapable secreting IgA failed restore acid only moderately protected animals developing Collectively, results clearly demonstrate regulate synthesis mucosal may be particularly for driving effect.